147388-83-8

147388-83-8 structure

Name: 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
Chemical Name: ABT-418 hydrochloride
CAS Number: 147388-83-8
Molecular Formula: C₉H₁₅ClN₂O
Molecular Weight: 202.68100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2016-11-22 10:28:42
Modify Date: 2024-01-14 12:21:00
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].

Name	ABT-418 hydrochloride
Synonyms	3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole,hydrochloride

Description	ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	nAChRs[1][2]
In Vivo	ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1]. Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1]. ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2]. ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2]. Animal Model: Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2] Dosage: 0.6 mg/kg Administration: Intraperitoneal injection; once daily; for two weeks Result: Effectively improved spatial memory.
References	[1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5.

Boiling Point	249.2ºC at 760 mmHg
Molecular Formula	C₉H₁₅ClN₂O
Molecular Weight	202.68100
Flash Point	104.5ºC
Exact Mass	202.08700
PSA	29.27000
LogP	2.48960
Vapour Pressure	0.0232mmHg at 25°C

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H310-H330
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Hazard Codes	T+
Risk Phrases	R26/27/28
Safety Phrases	S22
RIDADR	UN 2811 6.1/PG 1

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