65100-45-0

65100-45-0 structure

Name: Imipramine-d6
Chemical Name: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-bis(trideuteriomethyl)propan-1-amine
CAS Number: 65100-45-0
Molecular Formula: C₁₉H₁₈D₆N₂
Molecular Weight: 286.44400
Catalog: Signaling Pathways Neuronal Signaling Serotonin Transporter
Create Date: 2017-09-02 20:11:05
Modify Date: 2024-01-10 21:28:42
Imipramine-d6 is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion[1][2][3][4][5].

Name	3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-bis(trideuteriomethyl)propan-1-amine
Synonyms	Imipramine-d6

Description	Imipramine-d6 is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion[1][2][3][4][5].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. [3]. Yasuda S, et al. Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor. Cell Mol Neurobiol. 2014 Nov;34(8):1199-208. [4]. Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20. [5]. Erburu M, et al. Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex. Pharmacol BiochemBehav. 2015 Aug;135:227-36. [6]. Nagasawa M, et al. Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats. Eur J Pharmacol. 2015 Sep 5;762:127-35. [7]. Tokarski K, et al. Imipramine counteracts corticosterone-induced alterations in the effects of the activation of 5-HT(7) receptors in rat hippocampus. J Physiol Pharmacol. 2009 Jun;60(2):83-8. [8]. Mariadelva Catalano, et al. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2020; 9(1): 1703244.

Density	1.064g/cm3
Boiling Point	403.089ºC at 760 mmHg
Molecular Formula	C₁₉H₁₈D₆N₂
Molecular Weight	286.44400
Flash Point	179.73ºC
Exact Mass	286.23200
PSA	6.48000
LogP	3.94000
Index of Refraction	1.575

Hazard Codes	T+

65100-45-0	1189880-70-3
1216808-01-3	165602-94-8
113-52-0	70738-29-3
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1169943-24-1	96705-18-9