66054-36-2

66054-36-2 structure

Name: Tunicamycin V
Chemical Name: tunicamycin A
CAS Number: 66054-36-2
Molecular Formula: C₃₈H₆₂N₄O₁₆
Molecular Weight: 830.91600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-04-30 16:17:31
Modify Date: 2024-01-10 17:41:30
Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35 μM. Tunicamycin V has antibacterial activties[1][2].

Name	tunicamycin A
Synonyms	(+)-tunicamycin V tunicamycin B tunicamycin V tunicamycin-V tunicamycin

Description	Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35 μM. Tunicamycin V has antibacterial activties[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))[1]
In Vitro	Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)[2].
References	[1]. Kazuki Yamamoto, et al. Structural requirement of tunicamycin V for MraY inhibition. Bioorg Med Chem. 2019 Apr 15;27(8):1714-1719. [2]. Kazuki Yamamoto, et al. Total Synthesis of Tunicamycin V. Org Lett. 2018 Jan 5;20(1):256-259.