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957-75-5

957-75-5 structure
957-75-5 structure
  • Name: 5-Bromouridine
  • Chemical Name: 5-bromouridine
  • CAS Number: 957-75-5
  • Molecular Formula: C9H11BrN2O6
  • Molecular Weight: 323.10
  • Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
  • Create Date: 2018-05-06 08:00:00
  • Modify Date: 2025-08-23 13:45:31
  • 5-Bromouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Name 5-bromouridine
Synonyms 5-bromo-uridin
5-Br-rU
Uridine, 5-bromo-
EINECS 213-486-6
5-Bromouracil ribonucleoside
bromouridine
5-BrU
5'-BROMOURIDINE
5-Bromouracil-1-β-D-ribofuranoside
5-Bromouridine
5-BROMO-URIDINE(5-BRU)
5-bromo-UMP
MFCD00006528
1-β-ribofuranosyl-5-bromo-uracil
5-Bromo-D-uridine
Description 5-Bromouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 2.0±0.1 g/cm3
Melting Point 180-182 °C (dec.)(lit.)
Molecular Formula C9H11BrN2O6
Molecular Weight 323.10
Exact Mass 321.980042
PSA 124.78000
LogP -0.92
Index of Refraction 1.691

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU7300000
CHEMICAL NAME :
Uridine, 5-bromo-
CAS REGISTRY NUMBER :
957-75-5
BEILSTEIN REFERENCE NO. :
0033664
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H11-Br-N2-O6
MOLECULAR WEIGHT :
323.13
WISWESSER LINE NOTATION :
T6NVMVJ EE A- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,205,1980
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,205,1980
Hazard Codes Xn
Safety Phrases S22-S24/25
WGK Germany 3
RTECS YU7300000
58-96-8 structure

58-96-8

~97%

957-75-5 structure

957-75-5

Literature: Kumar; Wiebe; Knaus Canadian Journal of Chemistry, 1994 , vol. 72, # 9 p. 2005 - 2010
105659-31-2 structure

105659-31-2

~85%

957-75-5 structure

957-75-5

Literature: Asakura, Jun-ichi; Robins, Morris J. Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933
58-96-8 structure

58-96-8

~58%

957-75-5 structure

957-75-5

114743-19-0 structure

114743-19-0

Literature: Synthesis, , vol. No. 9, p. 829 - 831
4105-38-8 structure

4105-38-8

~%

957-75-5 structure

957-75-5

Literature: Journal of Organic Chemistry, , vol. 55, # 16 p. 4928 - 4933
13035-61-5 structure

13035-61-5

~%

957-75-5 structure

957-75-5

Literature: Bioorganic and Medicinal Chemistry, , vol. 20, # 24 p. 7184 - 7193
3066-86-2 structure

3066-86-2

~%

957-75-5 structure

957-75-5

58461-29-3 structure

58461-29-3

Literature: Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 40, # 9 p. 768 - 775
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