Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 5α-Dihydroprogesterone
Price: ￥818.0/1g
Purity: 97.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-alpha-Dihydroprogesterone
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: 5-alpha-Dihydroprogesterone
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 566-65-4 5-alpha-Dihydroprogesterone
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Purity: 99.0%
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Contact: Anson

566-65-4

566-65-4 structure

566-65-4 structure

Name: 5α-Dihydroprogesterone
Chemical Name: 5α-pregnane-3,20-dione
CAS Number: 566-65-4
Molecular Formula: C₂₁H₃₂O₂
Molecular Weight: 316.478
Catalog: Inorganic chemical industry Inorganic salt Hydride, nitride, azide Hydride
Create Date: 2018-06-26 08:42:04
Modify Date: 2024-01-05 22:37:46
5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.

Name	5α-pregnane-3,20-dione
Synonyms	5a-Dihydroprogesterone 4-07-00-02199 (Beilstein Handbook Reference) Pregnane-3,20-dione, (5-α)- (9CI) 5alpha-Pregnan-3,20-dione MFCD00067132 Allopregnane-3,20-dione (5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one UNII:98G4S1OH0Z 5α-pregnane-3,20-dione (5α)-Pregnane-3,20-dione Pregnane-3,20-dione 5α-dihydroprogesterone EINECS 209-297-3 Allopregnan-3,20-dione 3,20-Allopregnanedione 5alpha-pregnane-3,20-dione 3,20-Dioxo-5a-pregnane 5a-Pregnan-3,20-dione Pregnane-3,20-dione, (5α)- Pregnane-3,20-dione, (5α)- (9CI) 3,20-Dioxo-5alpha-pregnane 5-α-pregnane-3,20-dione allopregnandione 5alpha-Dihydroprogesterone 5a-Pregnane-3,20-dione 5α-Pregnane-3,20-dione (8CI) (5Alpha)-Pregnane-3,20-dione

Description	5a-Pregnane-3,20-dione is the endogenous progesterone metabolite.
Related Catalog	Research Areas >> Endocrinology Natural Products >> Flavonoids
Target	Human Endogenous Metabolite
In Vitro	5a-Pregnane-3,20-dione decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerizes F-actin in MCF-7 breast cancer cells[1].
References	[1]. Wiebe JP, et al. The endogenous progesterone metabolite, 5a-pregnane-3,20-dione, decreases cell-substrate attachment, adhesion plaques, vinculin expression, and polymerized F-actin in MCF-7 breast cancer cells. Endocrine. 2001 Oct;16(1):7-14.

Density	1.0±0.1 g/cm3
Boiling Point	429.2±38.0 °C at 760 mmHg
Melting Point	204 °C
Molecular Formula	C₂₁H₃₂O₂
Molecular Weight	316.478
Flash Point	160.3±23.8 °C
Exact Mass	316.240234
PSA	34.14000
LogP	4.31
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.516

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4157150

CHEMICAL NAME :: 5-beta-Pregnane-3,20-dione

CAS REGISTRY NUMBER :: 566-65-4

BEILSTEIN REFERENCE NO. :: 2058506

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H32-O2

MOLECULAR WEIGHT :: 316.53

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968

Hazard Codes	Xi
WGK Germany	3
RTECS	TU4157150

Precursor 9
57-83-0 516-53-0 6170-12-3 516-55-2
7680-01-5 145-13-1 566-58-5 516-54-1
1778-02-5
DownStream 6
567-02-2 38398-32-2 1264737-31-6 516-55-2
516-54-1 566-57-4