120786-18-7
120786-18-7 structure
- Name: Huperzine A
- Chemical Name: (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
- CAS Number: 120786-18-7
- Molecular Formula: C15H18N2O
- Molecular Weight: 242.316
- Catalog: API Nervous system medication Cholinergic
- Create Date: 2018-09-11 16:12:27
- Modify Date: 2025-08-21 19:14:46
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Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease.
| Name | (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one |
|---|---|
| Synonyms |
(+-)-HUPERZINE A
5,9-METHANOCYCLOOCTA[B]PYRIDIN-2(1H)-ONE,5-AMINO-11-ETHYLIDENE-5,6,9,10-TETRAHYDRO-7-METHYL-, (11E)- HUPERZINE A (+/-)- MFCD00171439 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (11E)- (±)-Huperzine A (+/-)-HUPERZINE A (+/-)-Huperazine A Huperzine A (13E)-1-Amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0]trideca-2(7),3,10-trien-5-one (11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one |
| Description | Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 505.0±50.0 °C at 760 mmHg |
| Molecular Formula | C15H18N2O |
| Molecular Weight | 242.316 |
| Flash Point | 259.2±30.1 °C |
| Exact Mass | 242.141907 |
| PSA | 58.88000 |
| LogP | 0.71 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.626 |
| Storage condition | 2-8°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H315-H319-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | 23/24/25-36/37/38 |
| Safety Phrases | 26-36/37/39-45 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | PB9185700 |