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82-57-5

82-57-5 structure
82-57-5 structure
  • Name: Visnagin
  • Chemical Name: 4-methoxy-7-methylfuro[3,2-g]chromen-5-one
  • CAS Number: 82-57-5
  • Molecular Formula: C13H10O4
  • Molecular Weight: 230.216
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-03-17 08:00:00
  • Modify Date: 2025-08-25 12:40:12
  • Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2].
Name 4-methoxy-7-methylfuro[3,2-g]chromen-5-one
Synonyms Visnagidin
Visnagin
5-methoxy-2-methylfuranobenzopyran-4-one
EINECS 201-430-3
Visnacorin
Desmethoxykhellin
MFCD00005008
5H-Furo[3,2-g][1]benzopyran-5-one, 4-methoxy-7-methyl-
Visnagine
5-Methoxy-2-methylfuranochromone
4-Methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one
4-Methoxy-7-methyl-5H-furo[3,2-g]chromen-5-one
Description Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles[1][2].
Related Catalog
In Vitro Visnagin (10 µM; for 4, 8, 16, 24 h) induces CYP1A1 transcription in HepG2 cells[1]. Visnagin (10 µM; for 16 h) elevates CYP1B1 gene expression in an aryl hydrocarbon receptor (AHR)-dependent manner, whereas MNF (3’-methoxy-4’-nitroflavone; 20 µM; pre-treated for 1 h) successfully counteracted this induction. Visnagin also enhances PAI-2 transcription in an AHR-dependent manner[1].
In Vivo Visnagin (10, 30, 60 mg/kg; ip; for 7 days) is effective in reducing plasma amylase and lipase levels and reduces Cerulein (50 μg/kg, six, hourly i.p. injections) induced oxidative stress in male Swiss albino mice (age: 6-8 weeks, weighing 20-25 g)[1]. Visnagin dose dependently decreases the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuates the levels of nuclear p65-NFκB. Visnagin improves the antioxidant defence by improving Nrf2 expression and halts pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells[1].
References

[1]. Radim Vrzal, et al. Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One. 2013 Sep 19;8(9):e74917.

[2]. Lakshmi Priya Pasari, et al. Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction. Biomed Pharmacother. 2019 Apr;112:108629.
Density 1.3±0.1 g/cm3
Boiling Point 378.2±42.0 °C at 760 mmHg
Melting Point 139-142 °C
Molecular Formula C13H10O4
Molecular Weight 230.216
Flash Point 182.5±27.9 °C
Exact Mass 230.057907
PSA 52.58000
LogP 2.26
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.613

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV1420000
CHEMICAL NAME :
5H-Furo(3,2-g)(1)benzopyran-5-one, 4-methoxy-7-methyl-
CAS REGISTRY NUMBER :
82-57-5
BEILSTEIN REFERENCE NO. :
0234955
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H10-O4
MOLECULAR WEIGHT :
230.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
832 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
123 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S3
RTECS LV1420000
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