Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
Price: ￥708.0/10mg ￥7358.0/250mg ￥1898.0/50mg
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: GSNO
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S-nitrosoglutathione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

57564-91-7

57564-91-7 structure

Name: L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
Chemical Name: S-nitrosoglutathione
CAS Number: 57564-91-7
Molecular Formula: C₁₀H₁₆N₄O₇S
Molecular Weight: 336.322
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2019-01-09 18:14:45
Modify Date: 2024-01-02 23:38:08
Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].

Name	S-nitrosoglutathione
Synonyms	L-γ-Glutamyl-S-nitroso-L-cysteinylglycine glycine, N-(N-L-γ-glutamyl-S-nitroso-L-cysteinyl)- Glycine, L-γ-glutamyl-S-nitroso-L-cysteinyl- S-Nitroso-L-glutathione S-NITROSOGLUTATHIONE MFCD00214341 EINECS 248-170-7

Description	Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity[5].
In Vivo	Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20[3]. Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, butup-regulates endothelial NOS expression in the flap vessels[4]. Animal Model: Male Lewis rats[4]. Dosage: 0.2 and 0.6 mg/kg. Administration: Slow intravenous injection via the opposite femoral vein into each rat. Result: Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.
References	[1]. Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176(12):2049-2062. [2]. D E Jensen, et al. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):659-68. [3]. Caneta Brown, et al. The effects of S-nitrosoglutathione and S-nitroso-N-acetyl-D, L-penicillamine in a rat model of pre-eclampsia. J Nat Sci Biol Med. 2013 Jul;4(2):330-5. [4]. Yur-Ren Kuo, et al. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma. 2004 Nov;57(5):1025-31. [5]. Eva Nozik-Grayck, et al. Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1057-65.

Density	1.7±0.1 g/cm3
Melting Point	>170ºC (dec.)
Molecular Formula	C₁₀H₁₆N₄O₇S
Molecular Weight	336.322
Exact Mass	336.073975
PSA	213.55000
LogP	-0.26
Index of Refraction	1.656
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0558000

CHEMICAL NAME :: Glycine, N-(N-L-gamma-glutamyl-2-nitroso-L-cysteinyl)-

CAS REGISTRY NUMBER :: 57564-91-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H16-N4-O7-S

MOLECULAR WEIGHT :: 336.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 5 umol/plate

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,3847,1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MC0558000
HS Code	2930909090

Precursor 9
70-18-8 116303-47-0 540-80-7 541-42-4
109-95-5 10288-17-2 41051-51-8 10311-10-1
110-46-3
DownStream 8
59-89-2 27025-41-8 70-18-8 67776-06-1
599-71-3 97512-84-0 1116-54-7 13081-14-6

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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