Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Corydaline
Price: ￥988.0/5mg ￥998.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Corydaline
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

518-69-4

518-69-4 structure

518-69-4 structure

Name: Corydaline
Chemical Name: corydaline
CAS Number: 518-69-4
Molecular Formula: C₂₂H₂₇NO₄
Molecular Weight: 369.454
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-05-02 08:00:00
Modify Date: 2024-01-02 14:18:34
Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

Name	corydaline
Synonyms	13aβ-Berbine, 2,3,9,10-tetramethoxy-13α-methyl- (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline d-Corydalin (13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline (13S-trans )-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine Corydaline (+) 6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-methyl-, (13S,13aR)- Berbine,2,3,9,10-tetramethoxy-13-methyl 2,3,9,10-Tetramethoxy-13a-methyl-13ab-berbine (13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline Corydalin Corydaline

Description	Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> AChE Natural Products >> Alkaloid Research Areas >> Neurological Disease
References	[1]. Xiao HT, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.

Density	1.2±0.1 g/cm3
Boiling Point	482.3±45.0 °C at 760 mmHg
Melting Point	135°
Molecular Formula	C₂₂H₂₇NO₄
Molecular Weight	369.454
Flash Point	135.7±25.9 °C
Exact Mass	369.194000
PSA	40.16000
LogP	4.19
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.600
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN0600000

CHEMICAL NAME :: Corydaline

CAS REGISTRY NUMBER :: 518-69-4

BEILSTEIN REFERENCE NO. :: 0096972

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H27-N-O4

MOLECULAR WEIGHT :: 369.50

WISWESSER LINE NOTATION :: T D6 B666 KN&TT&J C1 GO1 HO1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

29550-24-1 structure

29550-24-1

~%

518-69-4 structure

518-69-4

Literature: Manske Journal of the American Chemical Society, 1953 , vol. 75, p. 4928

883833-45-2 structure

883833-45-2

~%

518-69-4 structure

518-69-4

Literature: CVI PHARMACEUTICALS LIMITED; LIU, Haiyan; LI, Gaoping; WANG, Junbo; LIU, Jingwen Patent: WO2010/75469 A1, 2010 ; Location in patent: Page/Page column 62 ; WO 2010/075469 A1

74-88-4 structure

74-88-4

~%

518-69-4 structure

518-69-4

Literature: Dobbie; Lauder; Paliatseas Journal of the Chemical Society, 1901 , vol. 79, p. 89

5344-58-1 structure

5344-58-1

6018-35-5 structure

6018-35-5

~%

518-69-4 structure

518-69-4

Literature: Gadamer; Wagner Archiv der Pharmazie (Weinheim, Germany), 1902 , vol. 240, p. 36

87-69-4 structure

87-69-4

6018-35-5 structure

6018-35-5

~%

518-69-4 structure

518-69-4

Literature: Gadamer; Wagner Archiv der Pharmazie (Weinheim, Germany), 1902 , vol. 240, p. 36

Precursor 5
29550-24-1 74-88-4 5344-58-1 6018-35-5
87-69-4
DownStream 3
30045-16-0 577-68-4 518-90-1