22688-78-4

22688-78-4 structure

Name: Kaempferol-3-beta-O-glucuronide
Chemical Name: (2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
CAS Number: 22688-78-4
Molecular Formula: C₂₁H₁₈O₁₂
Molecular Weight: 462.360
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-12 13:44:15
Modify Date: 2025-08-22 18:09:50
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10[1][2].

Name	(2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonyms	5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl D-glucopyranosiduronic acid 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl β-D-glucopyranosiduronic acid Kaempferol 3-O-\|A-D-glucuronide 4H-1-Benzopyran-4-one, 3-(D-glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- 4H-1-Benzopyran-4-one, 3-(β-D-glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- Kaempferol-3-Glucuronide Kaempferol 3-glucuronide

Description	Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
References	[1]. Khajuria V, et al. Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model. Int Immunopharmacol. 2018;57:62-71. [2]. DuPont MS, et al. Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur J Clin Nutr. 2004;58(6):947-954.