Kaempferol-3-beta-O-glucuronide

Modify Date: 2024-01-07 20:48:24

Kaempferol-3-beta-O-glucuronide Structure
Kaempferol-3-beta-O-glucuronide structure
Common Name Kaempferol-3-beta-O-glucuronide
CAS Number 22688-78-4 Molecular Weight 462.360
Density 1.9±0.1 g/cm3 Boiling Point 876.8±65.0 °C at 760 mmHg
Molecular Formula C21H18O12 Melting Point 189-191 °C
MSDS N/A Flash Point 309.8±27.8 °C

 Use of Kaempferol-3-beta-O-glucuronide


Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10[1][2].

 Names

Name (2S,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonym More Synonyms

 Kaempferol-3-beta-O-glucuronide Biological Activity

Description Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10[1][2].
Related Catalog
References

[1]. Khajuria V, et al. Kaempferol-3-o-β-d-glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model. Int Immunopharmacol. 2018;57:62-71.

[2]. DuPont MS, et al. Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur J Clin Nutr. 2004;58(6):947-954.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 876.8±65.0 °C at 760 mmHg
Melting Point 189-191 °C
Molecular Formula C21H18O12
Molecular Weight 462.360
Flash Point 309.8±27.8 °C
Exact Mass 462.079834
PSA 207.35000
LogP 2.30
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.789
Storage condition ?20°C

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26

 Synonyms

5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl D-glucopyranosiduronic acid
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl β-D-glucopyranosiduronic acid
Kaempferol 3-O-|A-D-glucuronide
4H-1-Benzopyran-4-one, 3-(D-glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
4H-1-Benzopyran-4-one, 3-(β-D-glucopyranuronosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
Kaempferol-3-Glucuronide
Kaempferol 3-glucuronide