ART-IN-1

Names

[ Name ]:
ART-IN-1

Biological Activity

[Description]:

ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

TNKS2:22 μM (IC50)

PARP15:1.1 μM (IC50)

PARP2:19 μM (IC50)

PARP14:>100 μM (IC50)

PARP10:2.4 μM (IC50)

[In Vitro]

ART-IN-1 (compound 7) (0-100 µM) shows inhibition of PARP2, TNKS2, PARP10, PARP14, PARP15 with IC50s of 19, 22, 2.4, >100, 1.1 µM, respectively[1].

[References]

[1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₃NO₂S

[ Molecular Weight ]:
259.32

Related Compounds

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