Zoledronic acid hydrate

Names

[ Name ]:
Zoledronic acid hydrate

[Synonym ]:
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid,hydrate
Zoledronic acid monohydrate
Reclast
Zometa
[1-Hydroxy-2-(1H-imidazol-1-yl)-1,1-ethanediyl]bis(phosphonic acid) hydrate (1:1)
Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, hydrate (1:1)
(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate
MFCD08448695
Aclasta
1-Hydroxy-2-(1-imidazolyl)ethane-1,1-diphosphonic Acid Monohydrate
[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) hydrate (1:1)
Zoledronic acid hydrate
Zoledronic acid
Zoledronic acid (monohydrate)

Biological Activity

[Description]:

Zoledronic acid monohydrate is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Cancer

[In Vitro]

Zoledronic acid monohydrate induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2].

[References]

[1]. Scheper M, et al. A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. ibrogenesis Tissue Repair. 2010 Apr 1;3:6.

[2]. Wang L, et al. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation. Clin Exp Pharmacol Physiol. 2018 Jun 8.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
764ºC at 760 mmHg

[ Melting Point ]:
245 °C(dec.)

[ Molecular Formula ]:
C₅H₁₂N₂O₈P₂

[ Molecular Weight ]:
290.105

[ Flash Point ]:
415.8ºC

[ Exact Mass ]:
290.006897

[ PSA ]:
181.96000

[ Vapour Pressure ]:
1.53E-24mmHg at 25°C

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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