Diiodohydroxyquinoline

Names

[ CAS No. ]:
83-73-8

[ Name ]:
Diiodohydroxyquinoline

[Synonym ]:
Disoquin
Dyodin
Rafamebin
ZOAQUIN
Diiodo-oxyquinoline
8-Hydroxy-5,7-diiodoquinoline
EINECS 201-497-9
Searlequin
5,7-diiodoquinolin-8-ol
Yodoxin
5,7-Diiodooxine
Diiodohydroxyquinolin
MFCD00006789
8-Quinolinol, 5,7-diiodo-
Dinoleine
Embequin
IODOQUINOL
Diiodohydroxyquinoline
Stanquinate
Enterosept
Iodoquinol (USP)
Diodoquin
Ioquin
Direxiode
5,7-Diiodo-8-quinolinol
Diodoxylin
Diiodoquinol

Biological Activity

[Description]:

Diiodohydroxyquinoline is a topical therapeutic agent, with satisfactory antibacterial properties.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.5±0.1 g/cm3

[ Boiling Point ]:
401.8±45.0 °C at 760 mmHg

[ Melting Point ]:
>200 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₅I₂NO

[ Molecular Weight ]:
396.951

[ Flash Point ]:
196.8±28.7 °C

[ Exact Mass ]:
396.846039

[ PSA ]:
33.12000

[ LogP ]:
4.11

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.828

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5775000

CHEMICAL NAME :: 8-Quinolinol, 5,7-diiodo-

CAS REGISTRY NUMBER :: 83-73-8

BEILSTEIN REFERENCE NO. :: 0153639

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C9-H5-I2-N-O

MOLECULAR WEIGHT :: 396.95

WISWESSER LINE NOTATION :: T66 BNJ GI II JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 819 mg/kg/13D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Blood - oxidant related (GPD deficient) anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 120 gm/kg/2Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >40 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Liver - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,219,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80403 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ RTECS ]:
VC5775000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effects of oral administration of zinc and diiodohydroxyquinolein on plasma zinc levels of uremic patients.

Nephron 69(2) , 147-50, (1995)

Patients with chronic renal failure often have low plasma zinc (Zn) levels. Some factors that may account for abnormal Zn metabolism in these patients are low dietary Zn intake, a specific Zn transpor...

Chromatographic methods for simultaneous determination of diiodohydroxyquinoline and metronidazole in their binary mixture.

Pak. J. Pharm. Sci. 26(5) , 865-71, (2013)

Two chromatographic methods were developed for analysis ofdiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, diiodohydroxyquinoline and metronidazole were separated on TLC sil...

LC of pharmaceutically important halogenated 8-hydroxyquinolines after precolumn derivatization with Pd (II).

J. Pharm. Biomed. Anal. 27(5) , 813-20, (2002)

An accurate, sensitive, and selective reversed phase high performance liquid chromatographic (HPLC) method was developed for the analysis of two halogenated 8-hydroxyquinoline derivatives; clioquinol ...