Asenapine Maleate
Names
[ CAS No. ]:
85650-56-2
[ Name ]:
Asenapine Maleate
[Synonym ]:
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aS,12bS)-, (2Z)-2-butenedioate (1:1)
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate
Asenapine maleate
Asenapine
(3aS,12bS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate (1:1)
Saphris
Asenapine (maleate)
trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oxepino[4,5-C]pyrrolidino maleate
Sycrest
trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate
trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole maleate
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate
1H-Dibenz(2,3:6,7)oxepino(4,5-c)pyrrole,5-chloro-2,3,3a,12b-tetrahydro-2-methyl-,(3aR,12bR)-rel-,(2Z)-2-butenedioate (1:1)
Biological Activity
[Description]:
[Related Catalog]:
[Target]
5-HT1A Receptor:2.5 nM (Ki)
5-HT2A Receptor:0.06 nM (Ki)
5-HT2C Receptor:0.03 nM (Ki)
5-HT7 Receptor:0.13 nM (Ki)
D2 Receptor:1.3 nM (Ki)
D3 Receptor:0.42 nM (Ki)
D4 Receptor:1.1 nM (Ki)
[In Vitro]
[In Vivo]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
357.9ºC at 760 mmHg
[ Melting Point ]:
141-145°
[ Molecular Formula ]:
C21H20ClNO5
[ Molecular Weight ]:
401.84000
[ Flash Point ]:
170.2ºC
[ Exact Mass ]:
401.10300
[ PSA ]:
87.07000
[ LogP ]:
3.90820
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
H2O: ≥10mg/mL
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311
[ Hazard Codes ]:
Xn;N
[ Risk Phrases ]:
R22;R36/37/38;R50/53
[ Safety Phrases ]:
S26-S60-S61
[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution
[ HS Code ]:
29339900
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Neurosci. 35 , 9580-94, (2015)
Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des...
Asenapine maleate in situ forming biodegradable implant: an approach to enhance bioavailability.Int. J. Pharm. 477(1-2) , 64-72, (2014)
Biodegradable injectable in-situ forming implants (ISFI) correspond to an alternative parenteral depot system to microspheres and surgical implants. Objective of present work was to formulate and eval...
Asenapine maleate: a new drug for the treatment of schizophrenia and bipolar mania.Drugs Today (Barc) 45 , 865-76, (2009)
Schizophrenia and bipolar disorder are serious neuropsychiatric disorders with substantial health risks for patients that result in major socioeconomic burdens on society. Current therapeutic agents f...