Asenapine citrate
Names
[ CAS No. ]:
1411867-74-7
[ Name ]:
Asenapine citrate
Biological Activity
[Description]:
Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].
[Related Catalog]:
[Target]
5-HT1A Receptor:8.6 (pKi)
5-HT1B Receptor:8.4 (pKi)
5-HT2A Receptor:10.2 (pKi)
5-HT2B Receptor:9.8 (pKi)
5-HT2C Receptor:10.5 (pKi)
5-HT5 Receptor:8.8 (pKi)
5-HT6 Receptor:9.6 (pKi)
5-HT7 Receptor:9.9 (pKi)
α1-adrenergic receptor:8.9 (pKi)
Alpha-2A adrenergic receptor:8.9 (pKi)
Alpha-2B adrenergic receptor:9.5 (pKi)
Alpha-2C adrenergic receptor:8.9 (pKi)
D1 Receptor:8.9 (pKi)
D2 Receptor:8.9 (pKi)
D3 Receptor:9.4 (pKi)
D4 Receptor:9.0 (pKi)
H1 Receptor:9.0 (pKi)
H2 Receptor:8.2 (pKi)
[In Vivo]
Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H24ClNO8
[ Molecular Weight ]:
477.89