Azathramycin
Names
[ CAS No. ]:
76801-85-9
[ Name ]:
Azathramycin
[Synonym ]:
9-deokso-9a-aza-9a-homoeritromicin A
Desmethylazithromycin
1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
9a-N-desmethyl azithromycin
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2, 6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
DD-Azaerythromycin A
10-Dihydro-10-deoxo-11-azaerythromycin A
9-Deoxo-9a-aza-9a-homo Erythromycin A(Desmethyl Azithromycin)
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside
9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A
9a-aza-9-deoxo-9a-homoerythromycin A
9-deoxo-9a-aza-9a-homoerythromycin
Azaerythromycin A
UNII-4LSP9FJT5B
1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β -D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-
9-deoxo-9a-aza-9a-homoerythromycin A
Azathramycin
Biological Activity
[Description]:
[Related Catalog]:
[References]
[3]. Fernandez-Obregon AC. Azithromycin for the treatment of acne. Int J Dermatol. 2000 Jan;39(1):45-50.
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
815.2±65.0 °C at 760 mmHg
[ Melting Point ]:
126-136ºC
[ Molecular Formula ]:
C37H70N2O12
[ Molecular Weight ]:
734.958
[ Flash Point ]:
446.8±34.3 °C
[ Exact Mass ]:
734.492859
[ PSA ]:
188.87000
[ LogP ]:
3.11
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.536
[ Storage condition ]:
-20℃
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H319
[ Precautionary Statements ]:
P305 + P351 + P338
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Mol. Microbiol. 54(2) , 376-85, (2004)
Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, aza...
Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms.J. Chromatogr. Sci. 41(1) , 10-6, (2003)
A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation produ...
Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: synthesis and structure-activity relationship of its acyl derivatives.J. Antibiot. 40(7) , 1006-15, (1987)
Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of eryt...