Azathramycin structure
|
Common Name | Azathramycin | ||
|---|---|---|---|---|
| CAS Number | 76801-85-9 | Molecular Weight | 734.958 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 815.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C37H70N2O12 | Melting Point | 126-136ºC | |
| MSDS | N/A | Flash Point | 446.8±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of AzathramycinAzathramycin is an antibiotic. |
| Name | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one |
|---|---|
| Synonym | More Synonyms |
| Description | Azathramycin is an antibiotic. |
|---|---|
| Related Catalog | |
| References |
[3]. Fernandez-Obregon AC. Azithromycin for the treatment of acne. Int J Dermatol. 2000 Jan;39(1):45-50. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 815.2±65.0 °C at 760 mmHg |
| Melting Point | 126-136ºC |
| Molecular Formula | C37H70N2O12 |
| Molecular Weight | 734.958 |
| Flash Point | 446.8±34.3 °C |
| Exact Mass | 734.492859 |
| PSA | 188.87000 |
| LogP | 3.11 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | HRKNNHYKWGYTEN-UHFFFAOYSA-N |
| SMILES | CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)CNC(C)C(O)C1(C)O |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
|
~83%
Azathramycin CAS#:76801-85-9 |
| Literature: ALEMBIC LIMITED Patent: WO2009/156938 A2, 2009 ; Location in patent: Page/Page column 8 ; |
|
~%
Azathramycin CAS#:76801-85-9 |
| Literature: WO2007/80507 A2, ; Page/Page column 11 ; |
|
~44%
Azathramycin CAS#:76801-85-9 |
| Literature: Costa, Anna M.; Vilarrasa, Jaume Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3371 - 3375 |
|
~%
Azathramycin CAS#:76801-85-9 |
| Literature: Lee, Younjoo; Choi, Jun Yong; Fu, Hong; Harvey, Colin; Ravindran, Sandeep; Roush, William R.; Boothroyd, John C.; Khosla, Chaitan Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 2792 - 2804 |
|
~%
Azathramycin CAS#:76801-85-9 |
| Literature: Journal of Medicinal Chemistry, , vol. 54, # 8 p. 2792 - 2804 |
|
Peptide-mediated macrolide resistance reveals possible specific interactions in the nascent peptide exit tunnel.
Mol. Microbiol. 54(2) , 376-85, (2004) Expression of specific short peptides can render cells resistant to macrolide antibiotics. Peptides conferring resistance to structurally different macrolides including oleandomycin, azithromycin, aza... |
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Quantitative thin-layer chromatographic method of analysis of azithromycin in pure and capsule forms.
J. Chromatogr. Sci. 41(1) , 10-6, (2003) A validated stability-indicating thin-layer chromatographic (TLC) method of the analysis of azithromycin (AZT) in bulk and capsule forms is developed. Both AZT potential impurity and degradation produ... |
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Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A: synthesis and structure-activity relationship of its acyl derivatives.
J. Antibiot. 40(7) , 1006-15, (1987) Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A (5), the new 15-membered semi-synthetic macrolide antibiotic with nitrogen as additional atom in the aglycone ring of eryt... |
| 9-deokso-9a-aza-9a-homoeritromicin A |
| Desmethylazithromycin |
| 1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |
| 9a-N-desmethyl azithromycin |
| (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2, 6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |
| DD-Azaerythromycin A |
| 10-Dihydro-10-deoxo-11-azaerythromycin A |
| 9-Deoxo-9a-aza-9a-homo Erythromycin A(Desmethyl Azithromycin) |
| (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside |
| 9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A |
| 9a-aza-9-deoxo-9a-homoerythromycin A |
| 9-deoxo-9a-aza-9a-homoerythromycin |
| Azaerythromycin A |
| UNII-4LSP9FJT5B |
| 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β -D-xylo-hexopyranosyl]oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- |
| 9-deoxo-9a-aza-9a-homoerythromycin A |
| Azathramycin |