LY56110

Names

[ Name ]:
LY56110

[Synonym ]:
5-[(4-chlorophenyl)(4-chlorophenyl)methyl]pyrimidine
5-(Bis(4-chlorophenyl)methyl)pyrimidine

Biological Activity

[Description]:

LY56110 is an orally active aromatase inhibitor. LY56110 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 2.5 and 11 μΜ, respectively. LY56110 can be used for neurological disorder study[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[References]

[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604.

[2]. O'Neill LA, et al. Effect of estrogen inhibitors on conceptus estrogen synthesis and development in the gilt. Domest Anim Endocrinol. 1991;8(1):139-153.

Chemical & Physical Properties

[ Density]:
1.296g/cm3

[ Boiling Point ]:
438.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₂Cl₂N₂

[ Molecular Weight ]:
315.20

[ Flash Point ]:
251.5ºC

[ Exact Mass ]:
314.03800

[ PSA ]:
25.78000

[ LogP ]:
4.96360

[ Vapour Pressure ]:
1.79E-07mmHg at 25°C

[ Index of Refraction ]:
1.625

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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