LY43578

Names

[ CAS No. ]:
26766-35-8

[ Name ]:
LY43578

[Synonym ]:
bis(4-chlorophenyl)(pyrimidin-5-yl) methanol
Bis(4-chlorophenyl)(5-pyrimidinyl)methanol

Biological Activity

[Description]:

LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

[References]

[1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604.  

[2]. Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186.  

Chemical & Physical Properties

[ Density]:
1.376g/cm3

[ Boiling Point ]:
494.9ºC at 760mmHg

[ Molecular Formula ]:
C17H12Cl2N2O

[ Molecular Weight ]:
331.20

[ Flash Point ]:
253.1ºC

[ Exact Mass ]:
330.03300

[ PSA ]:
46.01000

[ LogP ]:
4.06760

[ Vapour Pressure ]:
1.31E-10mmHg at 25°C

[ Index of Refraction ]:
1.643

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream