Glucocorticoid receptor-IN-2

Names

[ CAS No. ]:
2664932-65-2

[ Name ]:
Glucocorticoid receptor-IN-2

Biological Activity

[Description]:

Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1]. Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1].

[References]

[1]. Sheng Su, et al. Benzopyrazole compound. WO2021136429.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H20F4N6O2

[ Molecular Weight ]:
512.46

Related Compounds

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