2664932-65-2

2664932-65-2 structure

Name: Glucocorticoid receptor-IN-2
Chemical Name: Glucocorticoid receptor-IN-2
CAS Number: 2664932-65-2
Molecular Formula: C₂₅H₂₀F₄N₆O₂
Molecular Weight: 512.46
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2022-06-30 12:23:46
Modify Date: 2024-01-10 12:02:37
Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].

Name	Glucocorticoid receptor-IN-2

Description	Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Glucocorticoid receptor-IN-2 (Compound WX019) inhibits human peripheral blood mononuclear cells TNF-α with an IC50 of 0.98 nM[1]. Glucocorticoid receptor-IN-2 shows inhibitory effect on CYP3A4 with an IC50 of 9.12 µM[1].
References	[1]. Sheng Su, et al. Benzopyrazole compound. WO2021136429.

Molecular Formula	C₂₅H₂₀F₄N₆O₂
Molecular Weight	512.46