Glucocorticoid receptor-IN-1

Names

[ CAS No. ]:
2662908-25-8

[ Name ]:
Glucocorticoid receptor-IN-1

Biological Activity

[Description]:

Glucocorticoid receptor-IN-1 (Compound WX002) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-1 exhibits very good transcriptional repressive activity with an IC50 of 2.11 nM against hMMP1, and transcriptional activation activity with an EC50 of 5.59 nM against MMTV[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

Glucocorticoid receptor-IN-1 (Compound WX002) shows inhibitory effect on CYP3A4 with an IC50 of 16.7 µM[1].

[References]

[1]. Guoli Zhang, et al. Benzo[d][1,2,3]triazole ether compound. WO2021136431.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H19F4N7O2

[ Molecular Weight ]:
513.45

Related Compounds