σ1 Receptor/μ Opioid receptor modulator 1

Names

[ CAS No. ]:
2412700-00-4

[ Name ]:
σ1 Receptor/μ Opioid receptor modulator 1

Biological Activity

[Description]:

σ1 Receptor/μ Opioid receptor modulator 1 (Compound 44) is a potent σ1 receptor antagonist and μ opioid receptor agonist with Kis of 1.86 nM and 2.1 nM, respectively.σ1 Receptor/μ Opioid receptor modulator 1 exhibits potent analgesic activity. σ1 Receptor/μ Opioid receptor modulator 1 can be used for the research of neuropathic pain[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[References]

[1]. Jiaying Xiong, et al. Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain. Eur J Med Chem. 2020 Apr 1;191:112144.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H31FN2O2

[ Molecular Weight ]:
398.51

Related Compounds

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