GW 833972A

Names

[ Name ]:
GW 833972A

[Synonym ]:
2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride

Biological Activity

[Description]:

GW 833972A is a selective CB2 receptor agonist. GW 833972A inhibits induced nerve depolarization and citric acid-induced cough in animal models[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

hCB2-R:7.3 (pEC50)

rat CB2-R:7.5 (pEC50)

[In Vitro]

GW 833972A (0.3-300 μM; 10 min) 抑制辣椒素诱导的人和豚鼠去极化，还抑制前列腺素 E(2) 和高渗盐水诱导的豚鼠离体迷走神经去极化[1]。

[In Vivo]

GW 833972A (30 mg/kg, 2 mL/kg;腹腔注射; 单次剂量, 试验开始前 30 min 注射) 能够抑制柠檬酸诱导的有意识豚鼠的咳嗽症状。它还抑制辣椒素引起的主支气管血浆蛋白渗出现象[1]。

[References]

[1]. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008 Oct;155(4):547-57.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄Cl₂F₃N₅O

[ Molecular Weight ]:
444.23800

[ Exact Mass ]:
443.05300

[ PSA ]:
83.29000

[ LogP ]:
5.66720

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
25-36/37/38

[ Safety Phrases ]:
26-45

[ RIDADR ]:
UN 2811 6.1 / PGIII

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