<Suppliers Price>

GW 766994

Names

[ CAS No. ]:
408303-43-5

[ Name ]:
GW 766994

[Synonym ]:
4-{[({[(2S)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide
Z6213K1TPE
Benzamide, 4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-
GW-766994

Biological Activity

[Description]:

GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

CCR3:7.86 (pKi)


[In Vitro]

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis[1]. GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons[2].

[References]

[1]. Neighbour H, et al. Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16.

[2]. Zhu C, et al. Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Dec;54(10):7964-7978.


[Related Small Molecules]

INCB3344 | Cenicriviroc | INCB8761(PF-4136309) | RS504393 | RS-102895 hydrochloride | BX 471 | TAK-779 | Vercirnon | MK-0812 Succinate | AZD 2098 | CCX140 | INCB 3284 | ZK 756326 | CCR2-RA-[R] | BMS-813160

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
685.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H24Cl2N4O3

[ Molecular Weight ]:
451.346

[ Flash Point ]:
368.5±31.5 °C

[ Exact Mass ]:
450.122559

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.608

[ Storage condition ]:
2-8℃

Related Compounds