CCR2-RA-[R]
Names
[ CAS No. ]:
512177-83-2
[ Name ]:
CCR2-RA-[R]
[Synonym ]:
(R)-4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CCR2-RA-[R]
Biological Activity
[Description]:
CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.
[Related Catalog]:
[Target]
CCR2:103 nM (IC50, in U2OS-CCR2 cells)
[In Vitro]
The chemokine receptor CCR2 is a G protein-coupled receptor that is involved in many diseases characterized by chronic inflammation, and therefore a large variety of CCR2 small molecule antagonists has been developed. CCR2-RA-[R] displaces [125I]CCL2 from CCR2 with an pIC50 value of 6.1. The pKD of CCR2-RA-[R] for CCR2 and CCR5 is 8.8±0.1 and 7.0±0.1, respectively[2]. CCR2-RA-[R] inhibits CCR2 non-competitively by blocking activation-associated conformational changes and formation of the G protein-binding interface. The binding pocket of CCR2-RA-[R] is highly enclosed and possesses a balanced combination of hydrophobic and polar features, all of which favors pocket “druggability”[3].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.383g/cm3
[ Boiling Point ]:
482.6ºC at 760 mmHg
[ Molecular Formula ]:
C18H19ClFNO3
[ Molecular Weight ]:
351.80000
[ Flash Point ]:
245.7ºC
[ Exact Mass ]:
351.10400
[ PSA ]:
57.61000
[ LogP ]:
4.24070
[ Index of Refraction ]:
1.605