512177-83-2
512177-83-2 structure
- Name: CCR2-RA-[R]
- Chemical Name: 2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-, (5R)
- CAS Number: 512177-83-2
- Molecular Formula: C18H19ClFNO3
- Molecular Weight: 351.80000
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2018-11-25 05:26:31
- Modify Date: 2025-08-25 11:09:01
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CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.
| Name | 2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-, (5R) |
|---|---|
| Synonyms |
(R)-4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CCR2-RA-[R] |
| Description | CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM. |
|---|---|
| Related Catalog | |
| Target |
CCR2:103 nM (IC50, in U2OS-CCR2 cells) |
| In Vitro | The chemokine receptor CCR2 is a G protein-coupled receptor that is involved in many diseases characterized by chronic inflammation, and therefore a large variety of CCR2 small molecule antagonists has been developed. CCR2-RA-[R] displaces [125I]CCL2 from CCR2 with an pIC50 value of 6.1. The pKD of CCR2-RA-[R] for CCR2 and CCR5 is 8.8±0.1 and 7.0±0.1, respectively[2]. CCR2-RA-[R] inhibits CCR2 non-competitively by blocking activation-associated conformational changes and formation of the G protein-binding interface. The binding pocket of CCR2-RA-[R] is highly enclosed and possesses a balanced combination of hydrophobic and polar features, all of which favors pocket “druggability”[3]. |
| References |
| Density | 1.383g/cm3 |
|---|---|
| Boiling Point | 482.6ºC at 760 mmHg |
| Molecular Formula | C18H19ClFNO3 |
| Molecular Weight | 351.80000 |
| Flash Point | 245.7ºC |
| Exact Mass | 351.10400 |
| PSA | 57.61000 |
| LogP | 4.24070 |
| Index of Refraction | 1.605 |