4-FLUORO-4'-BROMOCHALCONE

Names

[ Name ]:
4-FLUORO-4'-BROMOCHALCONE

[Synonym ]:
2-Propen-1-one,1-(4-bromophenyl)-3-(4-fluorophenyl)
4-Fluoro-4'-bromochalcone

Biological Activity

[Description]:

CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[Target]

hMAO-B:0.031 μM (IC50)

hMAO-B:0.010 μM (Ki)

[References]

[1]. Thomas Parambi DG, et al. Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study. Comput Biol Chem. 2023 Aug;105:107899.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₀BrFO

[ Molecular Weight ]:
305.14

[ Exact Mass ]:
303.99000

[ PSA ]:
17.07000

[ LogP ]:
4.48430

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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