ABD-F

Names

[ Name ]:
ABD-F

[Synonym ]:
7-Fluoro-2,1,3-benzoxadiazole-4-sulfonamide
2,1,3-Benzoxadiazole-4-sulfonamide, 7-fluoro-
MFCD00036687

Biological Activity

[Description]:

4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F) is a fluorescent reagent for the sensitive and specific detection of thiols. 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole has low fluorescence background, and good stability of fluorophor[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Toyooka T, et al. New fluorogenic reagent having halogenobenzofurazan structure for thiols: 4-(aminosulfonyl)-7-fluoro-2, 1, 3-benzoxadiazole. Analytical chemistry, 1984, 56(13): 2461-2464.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
408.8±55.0 °C at 760 mmHg

[ Melting Point ]:
145-146ºC

[ Molecular Formula ]:
C₆H₄FN₃O₃S

[ Molecular Weight ]:
217.178

[ Flash Point ]:
201.0±31.5 °C

[ Exact Mass ]:
216.995743

[ PSA ]:
107.46000

[ LogP ]:
0.11

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
−20°C

[ Stability ]:
Light Sensitive

[ Water Solubility ]:
DMSO: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Quantification of glutathione in plasma samples by HPLC using 4-fluoro-7-nitrobenzofurazan as a fluorescent labeling reagent.

J. Chromatogr. Sci. 50 , 119-122, (2012)

A rapid and highly sensitive high-performance liquid chromatograpy method with fluorescence detection has been developed for determination of glutathione (GSH) in human plasma. A simple pre-column der...

Plasma thiols levels in Alzheimer's disease mice under diet-induced hyperhomocysteinemia: effect of S-adenosylmethionine and superoxide-dismutase supplementation.

J. Alzheimers Dis. 44(4) , 1323-31, (2015)

Widely confirmed reports were published on association between hyperhomocysteinemia, B vitamin deficiency, oxidative stress, and amyloid-β in Alzheimer's disease (AD). Homocysteine, cysteine, cysteiny...

Allosteric inhibition of PTP1B activity by selective modification of a non-active site cysteine residue.

Biochemistry 44(21) , 7704-12, (2005)

The fluorogenic reagent 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABDF) attenuates the functional activity of the protein tyrosine phosphatase PTP1B by reacting selectively with a single cystei...

Related Compounds

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