ABD-1970
Names
[ CAS No. ]:
2010154-82-0
[ Name ]:
ABD-1970
Biological Activity
[Description]:
ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL); ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg; ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production.
[References]
References 1. Clapper JR, et al. J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296. View Related Products by Target Monoacylglycerol Lipase (MAGL)
Chemical & Physical Properties
[ Molecular Formula ]:
C21H24ClF6N3O3
[ Molecular Weight ]:
515.881
Related Compounds
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