2010154-82-0
2010154-82-0 structure
- Name: ABD-1970
- Chemical Name: ABD-1970
- CAS Number: 2010154-82-0
- Molecular Formula: C21H24ClF6N3O3
- Molecular Weight: 515.881
- Create Date: 2020-01-12 12:49:50
- Modify Date: 2023-02-25 20:44:16
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ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL); ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg; ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production.
| Name | ABD-1970 |
|---|
| Description | ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL); ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg; ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production. |
|---|---|
| References | References 1. Clapper JR, et al. J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296. View Related Products by Target Monoacylglycerol Lipase (MAGL) |
| Molecular Formula | C21H24ClF6N3O3 |
|---|---|
| Molecular Weight | 515.881 |