dorsomorphin
Names
[ CAS No. ]:
866405-64-3
[ Name ]:
dorsomorphin
[Synonym ]:
Dorsomorphin
BML-275
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-
Compound C
6-{4-[2-(1-Piperidinyl)ethoxy]phenyl}-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine
AMPK Inhibitor,Compound C
Biological Activity
[Description]:
[Related Catalog]:
[Target]
AMPK:109 nM (Ki)
Autophagy
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Molecular Formula ]:
C24H25N5O
[ Molecular Weight ]:
399.488
[ Exact Mass ]:
399.205902
[ PSA ]:
55.55000
[ LogP ]:
2.39
[ Index of Refraction ]:
1.670
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332
[ Precautionary Statements ]:
P280
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
20/21/22
[ Safety Phrases ]:
36/37
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Oncol. Lett. 8(5) , 1993-1999, (2014)
Obesity, diabetes and insulin resistance are marked risk factors that promote the development of type I endometrial cancer. Previous studies have demonstrated that insulin-like growth factor 1 (IGF-1)...
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.Autophagy 11 , 1114-29, (2015)
Autophagy is induced during differentiation of human monocytes into macrophages that is mediated by CSF1/CSF-1/M-CSF (colony stimulating factor 1 [macrophage]). However, little is known about the mole...
Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway.Vascul. Pharmacol. 64 , 28-35, (2015)
Lipoic acid (LA) exerts therapeutic effects on cardiovascular diseases. However, the mechanisms underlying these therapeutic effects remain elusive. Endothelial nitric oxide synthase (eNOS) plays a cr...