Azido-PEG3-alcohol

Names

[ Name ]:
Azido-PEG3-alcohol

[Synonym ]:
2-(2-(2-AZIDOETHOXY)ETHOXY)ETHANOL
N3-EEET-OH
8-azido-3,6-dioxa-1-octanol
1-Azido-8-hydroxy-3,6-dioxaoctane
Azido-PEG3
8-Azido-3,6-dioxaoctanol solution
azidotriethylene glycol
8-Azido-3,6-dioxaoctanol
8-azido-3,6-dioxaoctan-1-ol

Biological Activity

[Description]:

Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₃N₃O₃

[ Molecular Weight ]:
175.18600

[ Flash Point ]:
-33℃

[ Exact Mass ]:
175.09600

[ PSA ]:
88.44000

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H315

[ Precautionary Statements ]:
P210

[ Hazard Codes ]:
F,Xi

[ Risk Phrases ]:
11-38

[ Safety Phrases ]:
16

[ RIDADR ]:
UN 2398 3 / PGII

[ WGK Germany ]:
3

[ HS Code ]:
2929909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2929909090

[ Summary ]:
2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis of New Phospholipids Linked to Steroid-Hormone Derivatives Designed for Two-Dimensional Crystallization of Proteins Lebeau, L., et al.

Helv. Chim. Acta 74 , 1697-1706, (1991)

Related Compounds

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