Tos-PEG3

Names

[ Name ]:
Tos-PEG3

[Synonym ]:
Ethanol,2-[2-(2-hydroxyethoxy)ethoxy]-,1-(4-methylbenzenesulfonate)
2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
triethyleneglycol monotosylate
2,2'-[ethane-1,2-diylbis(oxy)]bis[ethanol] mono(4-methylbenzenesulfonate)
p-toluenesulfonic acid 2-(2-(2-hydroxyethoxy)ethoxy)ethoxy ester
Tos-PEG4
HO(C2H4O)3Tos
toluene-4-sulfonic acid 2-[2-(2-hydroxy-ethoxy)ethoxy]ethyl ester
Ts(OCH2CH2)3OH
Tos-PEG3

Biological Activity

[Description]:

Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Noël M, et al. Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860.

Chemical & Physical Properties

[ Density]:
1.234±0.06 g/cm3

[ Boiling Point ]:
460.0±35.0 °C

[ Molecular Formula ]:
C₁₃H₂₀O₆S

[ Molecular Weight ]:
304.35900

[ Exact Mass ]:
304.09800

[ PSA ]:
90.44000

[ LogP ]:
1.80660

Safety Information

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%