Propargyl-PEG3-alcohol

Names

[ CAS No. ]:
208827-90-1

[ Name ]:
Propargyl-PEG3-alcohol

[Synonym ]:
1-O-propargyl triethylene glycol

Biological Activity

[Description]:

Propargyl-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Andrew P. Crew, et al. Brm targeting compounds and associated methods of use. US20190300521A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₆O₄

[ Molecular Weight ]:
188.22100

[ Exact Mass ]:
188.10500

[ PSA ]:
47.92000

Propargyl-PEG3-alcohol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds