MC-Val-Cit-PAB-MMAF

Names

[ Name ]:
MC-Val-Cit-PAB-MMAF

[Synonym ]:
MFCD28398145

Biological Activity

[Description]:

MC-Val-Cit-PAB-MMAF is a drug-linker conjugate for ADC with antitumor activity by using the tubulin inhibitor, MMAF, linked via cathepsin cleavable MC-Val-Cit-PAB.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Auristatin

[References]

[1]. Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₈H₁₀₃N₁₁O₁₆

[ Molecular Weight ]:
1330.61

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds

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