N-Benzhydrylpiperazine
Names
[ CAS No. ]:
841-77-0
[ Name ]:
N-Benzhydrylpiperazine
[Synonym ]:
Piperazine, 1-(diphenylmethyl)-
EINECS 212-667-7
N-Benzhydrylpiperazine
1-benzhydrylpiperazine
MFCD00038379
Piperazine, 1- (diphenylmethyl)-
1-(Diphenylmethyl)piperazine
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
365.1±32.0 °C at 760 mmHg
[ Melting Point ]:
90-93 °C
[ Molecular Formula ]:
C17H20N2
[ Molecular Weight ]:
252.354
[ Flash Point ]:
140.5±16.1 °C
[ Exact Mass ]:
252.162643
[ PSA ]:
15.27000
[ LogP ]:
2.85
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.584
[ Water Solubility ]:
0.45 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TL6465000
- CHEMICAL NAME :
- Piperazine, 1-(diphenylmethyl)-
- CAS REGISTRY NUMBER :
- 841-77-0
- BEILSTEIN REFERENCE NO. :
- 0222773
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H20-N2
- MOLECULAR WEIGHT :
- 252.39
- WISWESSER LINE NOTATION :
- T6M DNTJ DYR&R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,453,1972
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
TL6465000
[ Packaging Group ]:
I; II; III
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(9-10) , 605-9, (2011)
A rapid and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed and validated for quantification of cyclizine and its main metabolite norcyclizine in human plasma. Sam...
Oxidative metabolism of cinnarizine in rat liver microsomes.Biochem. Pharmacol. 44(7) , 1471-4, (1992)
The oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] to 1-(diphenylmethyl)piperazine (M-1), 1-(diphenylmethyl)-4-[3-(4'-hydroxyphenyl)-2-propenyl]pipera...
The reactions of polyhalogenated-2-nitro-1, 3-butadiene with alkylthio, thiomorpholine and piperazine derivatives. Ibis C and Deniz NG.Indian J. Chem. B 47(9) , 1407, (2008)