Benzhydrol

Names

[ CAS No. ]:
91-01-0

[ Name ]:
Benzhydrol

[Synonym ]:
1,1-diphenylmethanol
EINECS 202-033-8
Benzenemethanol, α-phenyl-
benzhydrylalcohol
a-Phenylbenzenemethanol
a-Phenylbenzyl Alcohol
BENZOHYDROL
diphenyl methylol
benzydrol
hydroxy-diphenyl methane
Diphenylmethanol
diphenyl-methanol
Benzhydrol
BNEZHYDROL
MFCD00004488
DIPHENYLCARBINOL
Ebastine Impurity 1

Biological Activity

[Description]:

Diphenylmethanol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

苯甲醇广泛用作医药（包括抗组胺药）、农用化学品、香料和其他有机化合物的中间体。在香水工业中用作定香剂。作为终止基团参与聚合反应。用作制备莫达非尼、苯甲托品和苯海拉明的前体。

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
299.0±0.0 °C at 760 mmHg

[ Melting Point ]:
65-67 °C(lit.)

[ Molecular Formula ]:
C₁₃H₁₂O

[ Molecular Weight ]:
184.23

[ Flash Point ]:
140.8±15.1 °C

[ Exact Mass ]:
184.088821

[ PSA ]:
20.23000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC7452000

CHEMICAL NAME :: Benzhydrol

CAS REGISTRY NUMBER :: 91-01-0

BEILSTEIN REFERENCE NO. :: 1424379

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H12-O

MOLECULAR WEIGHT :: 184.25

WISWESSER LINE NOTATION :: QYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,713,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,713,1979

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,405,1925 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83171 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 249 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DC7452000

[ HS Code ]:
2906210000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2906299090

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Semi-quantitative profile of regioisomeric monohydroxydiphenylmethane metabolites in rat urine, faeces and bile.

Xenobiotica 11(6) , 425-32, (1981)

1. Urine and faeces, and two-hour bile samples from adult male rats dosed with [14C]diphenylmethane were analysed for benzhydrol and 2- and 4-hydroxydiphenyl-methane by silica gel GF t.l.c. and 14C-de...

Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.

Bioorg. Med. Chem. 19 , 1930-1949, (2011)

To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin compounds...

Calorimetric study of glass transition in molecular liquids consisting of globular associates: dicyclorohexylmethanol and tricyclohexylmethanol.

J. Phys. Chem. B 116(13) , 3938-43, (2012)

Heat capacities of liquids and liquid-quenched glasses (LQGs) of dicyclorohexylmethanol (DCHM) and tricyclohexylmethanol (TCHM) were measured by adiabatic calorimetry. Upon cooling the liquid compound...