Docosahexaenoic acid ethyl ester

Names

[ CAS No. ]:
81926-94-5

[ Name ]:
Docosahexaenoic acid ethyl ester

[Synonym ]:
cis-4,7,10,13,16,19-docosahexaneoic acid ethyl ester
ethyl-ester all cis 4,7,10,13,16,19-docosahexaenoate
(all-Z)
DHA ethyl ester
4,7,10,13,16,19-docosahexaenoic acid ethyl ester
Doconexent [inn]
Docosahexaenoic Acid Ethyl Ester
4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid ethyl ester
(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid Ethyl Ester-d5
Ethyl (all-Z)-docosa-4,7,10,13,16,19-hexaenoate
Docosahexanoic acid-[D5]-ethylester

Biological Activity

[Description]:

Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[In Vivo]

Docosahexaenoic acid ethyl ester (DHA-EE) (500 mg/kg; IP; once daily for 7 days) enhances 6-OHDA-induced reduction of striatal dopamine level[2].

[References]

[1]. Dahms I, et al. Safety of docosahexaenoic acid (DHA) administered as DHA ethyl ester in a 9-month toxicity study in dogs. Food Chem Toxicol. 2016;92:50-57.

[2]. Kabuto H, et al. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Neurochem Res. 2009;34(7):1299-1303.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₆O₂

[ Molecular Weight ]:
356.54

[ Exact Mass ]:
355.26400

[ PSA ]:
40.13000

[ LogP ]:
5.99440

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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