81926-94-5

81926-94-5 structure

Name: Docosahexaenoic acid ethyl ester
Chemical Name: ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
CAS Number: 81926-94-5
Molecular Formula: C₂₄H₃₆O₂
Molecular Weight: 356.54
Catalog: Research Areas Metabolic Disease
Create Date: 2016-07-02 19:18:02
Modify Date: 2025-08-24 16:35:38
Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2].

Name	ethyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate
Synonyms	cis-4,7,10,13,16,19-docosahexaneoic acid ethyl ester ethyl-ester all cis 4,7,10,13,16,19-docosahexaenoate (all-Z) DHA ethyl ester 4,7,10,13,16,19-docosahexaenoic acid ethyl ester Doconexent [inn] Docosahexaenoic Acid Ethyl Ester 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid ethyl ester (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid Ethyl Ester-d5 Ethyl (all-Z)-docosa-4,7,10,13,16,19-hexaenoate Docosahexanoic acid-[D5]-ethylester

Description	Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vivo	Docosahexaenoic acid ethyl ester (DHA-EE) (500 mg/kg; IP; once daily for 7 days) enhances 6-OHDA-induced reduction of striatal dopamine level[2].
References	[1]. Dahms I, et al. Safety of docosahexaenoic acid (DHA) administered as DHA ethyl ester in a 9-month toxicity study in dogs. Food Chem Toxicol. 2016;92:50-57. [2]. Kabuto H, et al. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Neurochem Res. 2009;34(7):1299-1303.