Emicerfont

Names

[ CAS No. ]:
786701-13-1

[ Name ]:
Emicerfont

[Synonym ]:
unii-oj8eg4264p
emicerfont

Biological Activity

[Description]:

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

[Target]

IC50: 66 nM (CRF1 receptor)[1]

[In Vitro]

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM[1].

[In Vivo]

At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1].

[References]

[1]. Zorrilla EP, et al. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₄N₆O₂

[ Molecular Weight ]:
404.46500

[ Exact Mass ]:
404.19600

[ PSA ]:
79.01000

[ LogP ]:
2.88650

[ Storage condition ]:
2-8℃

Related Compounds

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