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NVS-CRF38

Names

[ CAS No. ]:
1207258-55-6

[ Name ]:
NVS-CRF38

[Synonym ]:
7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole
7-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-3-(4-methoxy-2-methyl-phenyl)-2,6-dimethyl-pyrazolo[5,1-b]oxazole

Biological Activity

[Description]:

NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.IC50 value: Target: CRF1 antagonist

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR
Research Areas >> Others

[References]

[1]. Stringer RA, et al. Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist. Xenobiotica. 2014 Apr 3.

[2]. Stringer RA, et al. 1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats. Drug Metab Dispos. 2014 Jul;42(7):1117-24.


[Related Small Molecules]

R-121919 | CP 376395 | Verucerfont | CP 316311 | Pexacerfont | CRF (bovine) trifluoroacetate salt | Emicerfont | Urocortin human | Urocortin rat | Urotensin I

Chemical & Physical Properties

[ Molecular Formula ]:
C19H21N5O2

[ Molecular Weight ]:
351.40200

[ Exact Mass ]:
351.17000

[ PSA ]:
70.38000

[ LogP ]:
3.72560

[ Storage condition ]:
2-8℃

Related Compounds