Urocortin human

Urocortin, human, a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively.

Signaling Pathways >> GPCR/G Protein >> CRFR

Peptides

Research Areas >> Neurological Disease

Ki: 0.4 nM (hCRF1, cell assay), 0.3 nM (rCRF2α, cell assay), and 0.5 nM (mCRF2β, cell assay)[1]

Urocortin, human is a selective agonist of CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively[1].

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].

[1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.

[2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.

R-121919 | CP 376395 | Verucerfont | CP 316311 | NVS-CRF38 | Pexacerfont | CRF (bovine) trifluoroacetate salt | Emicerfont | Urocortin rat | Urotensin I