786701-13-1

786701-13-1 structure

Name: Emicerfont
Chemical Name: 1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
CAS Number: 786701-13-1
Molecular Formula: C₂₂H₂₄N₆O₂
Molecular Weight: 404.46500
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2016-05-03 06:06:55
Modify Date: 2024-01-09 10:35:01
Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

Name	1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Synonyms	unii-oj8eg4264p emicerfont

Description	Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
Target	IC50: 66 nM (CRF1 receptor)[1]
In Vitro	Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM[1].
In Vivo	At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1].
References	[1]. Zorrilla EP, et al. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.