Emicerfont

Modify Date: 2025-08-25 09:25:21

Use of Emicerfont

Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.

Name	1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
Synonym	More Synonyms

Description	Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
Target	IC50: 66 nM (CRF1 receptor)[1]
In Vitro	Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM[1].
In Vivo	At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1].
References	[1]. Zorrilla EP, et al. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.

Molecular Formula	C₂₂H₂₄N₆O₂
Molecular Weight	404.46500
Exact Mass	404.19600
PSA	79.01000
LogP	2.88650
InChIKey	JFHJGXQFESYQGY-UHFFFAOYSA-N
SMILES	COc1ccc(N2CCc3c(-n4ccc(N5CCNC5=O)n4)cc(C)nc32)c(C)c1
Storage condition	2-8℃

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emicerfont

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Price: $1878/1mg

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