α-Conotoxin GIC

Names

[ CAS No. ]:
757236-92-3

[ Name ]:
α-Conotoxin GIC

Biological Activity

[Description]:

α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[Target]

IC50: 1.1 nM (hα3β2), 309 nM (hα4β2), 755 nM (hα3β4), >100,000 nM (hα1β1δ?)[1]


[References]

[1]. McIntosh JM, et al. Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J Biol Chem. 2002 Sep 13;277(37):33610-5.  

Chemical & Physical Properties

[ Molecular Formula ]:
C61H92N24O20S4

[ Molecular Weight ]:
1609.79

Related Compounds