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757236-92-3

757236-92-3 structure

757236-92-3 structure

Name: α-Conotoxin GIC
Chemical Name: α-Conotoxin GIC
CAS Number: 757236-92-3
Molecular Formula: C₆₁H₉₂N₂₄O₂₀S₄
Molecular Weight: 1609.79
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2024-04-08 18:56:18
Modify Date: 2025-09-18 10:13:57
α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM[1].

Name	α-Conotoxin GIC

Description	α-Conotoxin GIC is a potent and selective α3β2 nicotinic antagonist with an IC50 of 1.1 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 1.1 nM (hα3β2), 309 nM (hα4β2), 755 nM (hα3β4), >100,000 nM (hα1β1δ?)[1]
References	[1]. McIntosh JM, et al. Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors. J Biol Chem. 2002 Sep 13;277(37):33610-5.

Molecular Formula	C₆₁H₉₂N₂₄O₂₀S₄
Molecular Weight	1609.79

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