Macamide B

Names

[ Name ]:
Macamide B

[Synonym ]:
N-benzylpalmitamide
N-Benzyl-palmitinamid
N-benzyl-hexadecanamide
N-hexadecanoyl benzylamine
N-Benzyl-palmitamid
N-benzylhexylhexadecanamide

Biological Activity

[Description]:

N-Benzylpalmitamide is a macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Signaling Pathways >> Neuronal Signaling >> FAAH

Natural Products >> Alkaloid

Research Areas >> Others

[Target]

FAAH[1]

[In Vitro]

N-Benzylpalmitamide is an inhibitor of fatty acid amide hydrolase (FAAH), and shows 24.8% and 43.8% inhibition on FAAH at 10 μM and 500 μM, respectively[1].

[References]

[1]. Wu H, et al. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition. Bioorg Med Chem. 2013 Sep 1;21(17):5188-97.

[Related Small Molecules]

BIA 10-2474 | PF-04457845 | URB597 | biochanin A | JZL195 | PF-3845 | LY2183240 | JNJ-42165279 | FAAH-IN-2 | FAAH inhibitor 1 | 11C-MK-3168 | FAAH-IN-1 | SA72

Chemical & Physical Properties

[ Melting Point ]:
95-96℃

[ Molecular Formula ]:
C₂₃H₃₉NO

[ Molecular Weight ]:
345.56200

[ Exact Mass ]:
345.30300

[ PSA ]:
32.59000

[ LogP ]:
7.62440

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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