PHENIPRAZINE HYDROCHLORIDE

Names

[ CAS No. ]:
66-05-7

[ Name ]:
PHENIPRAZINE HYDROCHLORIDE

Biological Activity

[Description]:

Pheniprazine hydrochloride is a potent and long acting inhibitor of monoamine oxidase. Pheniprazine has the potential for the research of depression[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

[References]

[1]. HORITA A. beta-Phenylisopropylhydrazine, a potent and long acting monoamine oxidase inhibitor. J Pharmacol Exp Ther.

[2]. Stein, Larry, et al. Accelerated recovery from reserpine depression by monoamine oxidase inhibitors.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₅ClN₂

[ Molecular Weight ]:
186.68200

[ Exact Mass ]:
186.09200

[ PSA ]:
38.05000

[ LogP ]:
2.97410

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MV7400000

CHEMICAL NAME :: Hydrazine, (alpha-methylphenethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 66-05-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H14-N2.Cl-H

MOLECULAR WEIGHT :: 186.71

WISWESSER LINE NOTATION :: ZM1Y1&R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 18,617,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,20,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,125,1966

Related Compounds

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